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[DOI] [PMC free article] [PubMed] [Google Scholar] 154.Zhang X, Liu S, Newport GD, Paule MG, Callicott R, Thompson J, Liu F, Patterson TA, Berridge MS, Apana SM, Brown CC, Maisha MP, Hanig JP, Slikker W, Jr, Wang C

High copper levels may contribute to oxidative stress, neurological issues, or imbalances

These factors can increase safety risks compared to approved medications

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This epigenetic mechanism is consistent with the broader Khavinson framework for bioregulator peptides, which proposes that short peptide sequences (27 amino acids) can penetrate nuclear membranes and interact directly with DNA or chromatin-associated proteins to modulate tissue-specific gene expression